| Authors |
Juffre A, Gumz ML
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| Submitted By |
Michelle Gumz on 3/13/2024 |
| Status |
Published |
| Journal |
American journal of physiology. Renal physiology |
| Year |
2024 |
| Date Published |
3/1/2024 |
| Volume : Pages |
326 : F382 - F393 |
| PubMed Reference |
38174377 |
| Abstract |
Circadian rhythms are endogenous biological oscillations that regulate various
physiological processes in organisms, including kidney function. The kidney
plays a vital role in maintaining homeostasis by regulating water and
electrolyte balance, blood pressure, and excretion of metabolic waste products,
all of which display circadian rhythmicity. For this reason, studying the
circadian regulation of the kidney is important, and the time of day is a
biological and experimental variable that must be considered. Over the past
decade, considerable progress has been made in understanding the molecular
mechanisms underlying circadian regulation within the kidney. In this review,
the current knowledge regarding circadian rhythms in the kidney is explored,
focusing on the molecular clock machinery, circadian control of renal functions,
and the impact of disrupted circadian rhythms on kidney health. In addition,
parameters that should be considered and future directions are outlined in this
review.
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