| Authors |
Zhao S, Zhang X, Bailey K, Pai S, Zhao Y, Chen YS
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| Submitted By |
Yun-Sheng Chen on 7/29/2025 |
| Status |
Published |
| Journal |
Advanced science (Weinheim, Baden-Wurttemberg, Germany) |
| Year |
2025 |
| Date Published |
6/1/2025 |
| Volume : Pages |
12 : e2414306 |
| PubMed Reference |
40068102 |
| Abstract |
Growing evidence suggests a close link between acute kidney injury (AKI) and
disruptions in renal microcirculation. However, current non-invasive tools for
quantitatively monitoring structural and functional changes in renal
microcirculation remain limited, making early diagnosis difficult. To address
this challenge, this work introduces a label-free 3D multi-parametric imaging
technique that combines photoacoustic and super-resolution ultrasound imaging.
This approach provides high-resolution information on renal vasculature,
hemodynamics, and oxygenation. This system offers the ability to visualize the
entire renal vasculature at a resolution of 26 µm. In an AKI model, this work
demonstrates a 54% reduction in vascular density, a 14.1% decrease in renal
oxygenation, and a 61% decline in relative blood volume (rBV) 3 days
post-surgery. The progression of kidney disease is further confirmed through
blood tests and histopathological analysis of the collected kidney tissues.
These findings indicate that this 3D renal imaging technique holds substantial
potential to advance the understanding of renal physiology and offers a valuable
tool for investigating renal injury.
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