Publication

Innovative Technologies for Kidney Research: Three-Dimensional Imaging and
Quantification.

Authors	McLarnon SR, N'Guetta PY, O'Brien LL
Submitted By	Lori O'Brien on 10/31/2025
Status	Published
Journal	Seminars in nephrology
Year	2025
Date Published
Volume : Pages	Not Specified : 151671
PubMed Reference	41038727
Abstract	Image analysis has played a critical role in our understanding of kidney morphology, function, and disease. This analysis has been historically limited to visualizing defined regions within the kidney in two dimensions. However, in recent years, significant advancements in microscopy have facilitated three-dimensional imaging and analysis of large tissue specimens and, in some cases, whole organs or organism. The use of these microscopy techniques combined with tissue-clearing strategies has resulted in detailed, multidimensional views of complex structures and processes within the kidney. This review discusses advanced light microscopy applications and optical clearing protocols that have been successfully modified for use in the kidney. Furthermore, this review will highlight how quantification of three-dimensional images has been applied in the kidney and thus contributed to novel spatiotemporal insights. Semin Nephrol 36:x-xx © 20XX Elsevier Inc. All rights reserved.

Investigators with authorship

Name	Institution
Lori O'Brien	University of North Carolina at Chapel Hill

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