ISAC Award Program Application Concept

Gut microbiota and glomerular filtration rate regulation
Jennifer Pluznick   (Baltimore, MD)
Glomerular filtration rate (GFR) is the basic measurement of kidney function, and in healthy individuals it is carefully regulated to maintain optimum renal function. However, there are over 785,000 individuals in the United States who have reduced GFR such that they need dialysis or a transplant to survive. Unexpectedly, we have found a role for gut microbiota to modulate GFR: GFR is significantly elevated in mice when gut microbes are suppressed (a mixture of oral antibiotics) or eliminated (germ-free mice). In this proposal, we will pursue proof of principle studies to determine if modulating gut microbes is a viable approach to elevating GFR in renal disease. To achieve this, we will utilize mouse models to understand how gut microbes regulate renal function, and, to determine if suppressing or eliminating gut microbes can elevate GFR in a chronic kidney disease model. Thus, our expected breakthrough discovery is the ability to modulate gut microbiota in order to elevate GFR in chronic disease. This high-risk/high-reward proposal has the potential to change the way we think about GFR regulation, and to open an entirely new paradigm of GFR modulation in chronic disease.
Data for this report has not yet been released.

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